EPOR Protein (C-Term, Extracellular Domain)

Catalog No. ABIN1684690

This Recombinant EPOR protein is produced in HEK-293T Cells.

Quick Overview for EPOR Protein (C-Term, Extracellular Domain) (ABIN1684690)

Target: EPOR (Erythropoietin Receptor (EPOR))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293T Cells

Purity: > 97 %, as determined by SDS-PAGE and HPLC

Product Details

Protein Characteristics: C-Term, Extracellular Domain

Specificity: Optimized DNA sequence encoding extracellular domain of mouse erythropoietin receptor including a C-terminal His tag was expressed in HEK293 cells.

Characteristics: Recombinant mouse EPO receptor is a monomer protein consisting of37 amino acid residue subunits, due to glycosylation migrates as an approximately 35 kDa protein on SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Application Details

Restrictions: For Research Use only

Handling

Buffer: PBS solution, pH7.2

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.

Expiry Date: 12-24 months

Target Details

Target: EPOR (Erythropoietin Receptor (EPOR))

Alternative Name: EPOR

Background: Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is member of a distinct, structurally-related subclass of CC chemokines. MCP-4/CCL13 is a major chemoattractants for eosinophils, basophils monocytes and T lymphocytes. The MCP protein family bind to specific G-protein-coupled receptors, initiating a signal cascade within the cell. Expression of MCP-4/CCL13 mRNA and protein is greater in the sputum, epithelium, submucosal inflammatory cells and bronchoalveolar lavage fluid of asthmatics than in healthy individuals. Involvement of MCPs has also been demonstrated in renal inflammation and atopic dermatitis and the expression of this protein is also correlated with enhanced inflammatory immune responses during immunotherapy

UniProt: P14753

Pathways: JAK-STAT Signaling